Dose-finding study of153Sm-EDTMP in patients with poor-prognosis osteosarcoma

CD133 expression predicts lung metastasis and poor prognosis in osteosarcoma patients: A clinical and experimental study

Identifying prognostic factors for osteosarcoma (OS) aids in the selection of patients who require more aggressive management. CD133 has been found to be a prognostic factor of certain tumor types. However, the association between CD133 expression and the prognosis of OS remains unknown. In this study, we analyzed the association of CD133 expression in OS with clinical factors and overall survi...

Recurrent Implantation Failure Is More Frequently Seen in Female Patients with Poor Prognosis

Increased Six1 expression is associated with poor prognosis in patients with osteosarcoma

Sine oculis homeobox homolog 1 (Six1) is an evolutionarily conserved transcription factor that acts as master regulator of development and is frequently dysregulated in various types of cancer. Six1 has been demonstrated to be upregulated in human osteosarcoma cell lines compared with osteoblastic cell lines. However, the association of Six1 expression with the progression and prognosis of oste...

Polymeric immunoglobulin receptor expression is correlated with poor prognosis in patients with osteosarcoma

The prognosis of patients with osteosarcoma with distant metastasis and local recurrence remains poor. Increased expression of polymeric immunoglobulin receptor (pIgR) in tumor tissue has been detected in various types of cancer. However, the clinical significance of pIgR in osteosarcoma has yet to be elucidated. The present study aimed to investigate the prognostic value of pIgR in patients wi...

High expression of TRPM8 predicts poor prognosis in patients with osteosarcoma

The transient receptor potential melastatin member 8 (TRPM8) is a newly characterized oncoprotein involved in various malignant tumors. However, its expression pattern and biological function in osteosarcoma remain unclear. The present study aimed to explore the expression and prognostic significance of TRPM8 in osteosarcoma (OS). The results revealed that the expression of TRPM8 mRNA and prote...